Abstract
This project develops a biomechanical testing platform to evaluate the coating adherence of a new liquid biopsy device under realistic clinical conditions. A synthetic phantom of the female pelvic organs including the uterus, cervix, and vagina was constructed entirely from CAD, informed by MUHC patient MRI data and clinical guidance from Dr. Ribeiro. The phantom organs were fabricated with injection molding using Dragon Skin 10NV platinum-cure silicone rubber, cast into PLA multi-part molds designed in SolidWorks and 3D printed. This approach was selected over direct 3D printing through a weighted concept evaluation, as it best replicates the mechanical properties, surface compliance, and frictional behavior of biological pelvic tissue required for reliable coating adherence testing. To validate sample collection efficiency, a synthetic cervical fluid is introduced into the phantom during testing. The liquid biopsy device is to be subjected to a simulated clinical motion combining translational and rotary movement to collect the synthetic fluid, replicating the mechanical interaction between the device and endometrial tissue under realistic conditions.